Gin Rummy is a very popular variation that is usually played by two players. In this variation, players try to minimize the number of points in their hands at the conclusion of each round while forming 247 slotsruns or sets of cards. Because players must choose whether to knock to end the round or keep drawing cards to improve their hands, the game is known for its strategic depth. Indian Rummy is another popular variation that can have up to six players and is typically played with two decks of cards. One of the two sequences that players must create in Indian Rummy must be pure—that is, devoid of a joker.

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